Toxic epidermal necrosis - Ityhefu Epidermal Necrosis
☆ Kwiziphumo zika-2022 ze-Stiftung Warentest ezivela eJamani, ukwaneliseka kwabathengi ngeModelDerm bekungaphantsi kancinci kunokubonisana nge-telemedicine ehlawulweyo.
Uphawu lokulahleka kwesikhumba Ityhefu Epidermal Necrosis (Toxic epidermal necrosis)
References
Stevens-Johnson Syndrome (SJS) kunye Toxic Epidermal Necrolysis (TEN) ziimeko ezinqabileyo apho ulusu lufumana i-necrosis ebanzi kunye nokuchithwa. Ngokuphathelele unyango, i-cyclosporine iphumelele kakhulu kwi-SJS, ngelixa i-intravenous immunoglobulin (IVIg) kunye ne-corticosteroids isebenza kakuhle kwiimeko ze-SJS kunye ne-TEN.
Stevens-Johnson Syndrome (SJS) and Toxic Epidermal Necrolysis (TEN) are rare diseases that are characterized by widespread epidermal necrosis and sloughing of skin. Regarding treatment, cyclosporine is the most effective therapy for the treatment of SJS, and a combination of intravenous immunoglobulin (IVIg) and corticosteroids is most effective for SJS/TEN overlap and TEN.
Stevens-Johnson Syndrome (SJS) and Toxic Epidermal Necrolysis (TEN) are rare diseases that are characterized by widespread epidermal necrosis and sloughing of skin. Regarding treatment, cyclosporine is the most effective therapy for the treatment of SJS, and a combination of intravenous immunoglobulin (IVIg) and corticosteroids is most effective for SJS/TEN overlap and TEN.
Toxic epidermal necrolysis (TEN) kukusabela okunzulu kwesikhumba okubangelwa ngamayeza athile kunye nomsebenzi we-immune system, okubangelwa ukuchithwa okukhulu kwesikhumba sangaphandle (i-epidermis) , echaphazela ngaphezu kwe-30% yomzimba womzimba. I-TEN inezinga lokufa elingaphezu kwama-20%, amaxesha amaninzi ngenxa yosulelo kunye nobunzima bokuphefumla. Ukuyeka iyeza elibangela ukusabela, ukubonelela ngononophelo oluxhasayo, kunye nokusebenzisa unyango olongezelelweyo kunokuphucula umphumo. Uphononongo lwakutsha nje lubonise ukuba amayeza afana ne-cyclosporine, i-tumor necrosis factor alpha inhibitors, kunye nendibaniselwano ye-immune immune globulin kunye ne-corticosteroids inokuba luncedo, ngokusekelwe kwizilingo ezilawulwa ngokungahleliwe kunye nohlalutyo lwezifundo ezininzi.
Toxic epidermal necrolysis (TEN) is a serious skin reaction caused by certain medications and immune system activity, resulting in large-scale detachment of the outer skin layer (epidermis), affecting more than 30% of the body's surface. TEN has a mortality rate of over 20%, often due to infections and breathing difficulties. Stopping the medication causing the reaction, providing supportive care, and using additional treatments can improve the outcome. Recent studies have shown that drugs like cyclosporine, tumor necrosis factor alpha inhibitors, and a combination of intravenous immune globulin and corticosteroids can be helpful, based on randomized controlled trials and analyses of multiple studies.
Toxic epidermal necrolysis (TEN) is a serious skin reaction caused by certain medications and immune system activity, resulting in large-scale detachment of the outer skin layer (epidermis), affecting more than 30% of the body's surface. TEN has a mortality rate of over 20%, often due to infections and breathing difficulties. Stopping the medication causing the reaction, providing supportive care, and using additional treatments can improve the outcome. Recent studies have shown that drugs like cyclosporine, tumor necrosis factor alpha inhibitors, and a combination of intravenous immune globulin and corticosteroids can be helpful, based on randomized controlled trials and analyses of multiple studies.
Recent Advances: There is improved understanding of pain and morbidity with regard to the type and frequency of dressing changes. More modern dressings, such as nanocrystalline, are currently favored as they may be kept in situ for longer periods. The most recent evidence on systemic agents, such as corticosteroids and cyclosporine, and novel treatments, are also discussed.
Oyena nobangela uxhaphakileyo ngamayeza athile afana nelamotrigine, carbamazepine, allopurinol, antibiotics sulfonamide, kunye nevirapine. Imiba yomngcipheko ibandakanya i-HIV kunye ne-systemic lupus erythematosus. Unyango ngokwesiqhelo lwenzelwa esibhedlele njengakwiyunithi yokutsha okanye iyunithi yokhathalelo olukhulu.
○ Unyango
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